(fungi and bacteria) and prevents of virus-to-cell contact. CONDITIONS THAT BENEFIT FROM OZONE INJECTION THERAPY • • • • • • • Myofascial pain syndrome 5 Osteoarthritis 10 Lumbar disc herniation and sciatica 11,12 Rheumatoid arthritis 1 Plantar fasciitis 13 Carpal tunnel syndrome 14 Joint instability including those with Ehlers Danlos, a connective tissue disorder that often presents with ligament laxity, frequent joint sub-luxations and pain WHAT TO EXPECT FROM THE THERAPY There is often an immediate response with most experiencing improvement in stability and pain of the area. Patients are encouraged to stop any aggravating activities after the treatment to allow the area to heal, but continue gentle range of motion. Long term responses differ for each case and can take 3-5 treat-ments with some requiring maintenance ‘booster’s’ every 3-4 months. In summary, ozone is an effective clinical tool that has a wide variety of uses with minimal side effects. Its ef-fectiveness and safety has been shown in recent literature for the its ability to reduce pain and chronic oxidative stress for a number of acute and chronic conditions. Medical gas research, 7(3), 212–219. https://doi. org/10.4103/2045-9912.215752 5. Tony, K. Y. et al. (2015). Mitochondrial and Bioenergetic Dysfunction in Trauma-Induced Painful Peripheral Neuropathy. Molecular Pain. 11. Leung, L., & Cahill, C. M. (2010). TNF-alpha and neuropathic pain--a review. Journal of neuroinflammation, 7, 27. https:// doi.org/10.1186/1742-2094-7-27 Shallenberger, F. (2011). Principles and Applications of Ozone Therapy. A Practical Guide for Physicians Raeissadat, S. A. et al. (2018). Comparison of ozone and lidocaine injection efficacy vs dry needling in myofascial pain syndrome patients. Journal of pain research, 11, 1273– 1279. https://doi.org/10.2147/JPR.S164629 Tartari, A.P.S., Moreira, F.F., Pereira, M.C.D.S. et al. (2020). Anti-inflammatory Effect of Ozone Therapy in an Experimental Model of Rheumatoid Arthritis. Inflammation 43, 985–993. 6. 7. 8. 9. 10. Al-Jaziri, A. A., & Mahmoodi, S. M. (2008). Painkilling effect of ozone-oxygen injection on spine and joint osteoarthritis. Saudi medical journal, 29(4), 553–557. 11. Paoloni, M. et al. (2009). Intramuscular oxygen-ozone therapy in the treatment of acute back pain with lumbar disc herniation: a multicenter, randomized, double-blind, clinical trial of active and simulated lumbar paravertebral injection. Spine, 34(13), 1337–1344. https://doi.org/10.1097/ BRS.0b013e3181a3c18d 12. Bonetti M, et al.(2005).. Am J Neuroradiol. 26(5):996-1000. 13. Bahrami, M. H. et al. (2019). Local ozone (O2-O3) versus corticosteroid injection efficacy in plantar fasciitis treatment: a double-blinded RCT. Journal of pain research, 12, 2251–2259. https://doi.org/10.2147/JPR.S202045 14. Seyam, O., Smith, N. L., Reid, I., Gandhi, J., Jiang, W., & Khan, S. A. (2018). Clinical utility of ozone therapy for musculoskeletal disorders. Medical gas research, 8(3), 103–110. https://doi.org/10.4103/2045-9912.241075 Ozone injections are initiated after a comprehensive assessment of the pain and any pertinent orthopedic tests. The injections themselves cause very little discomfort (other than some pressure or tenderness as the gas is injected into the area). REFERENCES 1. 2. Stoker G. (1902). Ozone in Chronic Middle-Ear Deafness. The Lancet. 160(4131):1187-1188. Bocci, V., Borrelli, E., Zanardi, I., & Travagli, V. (2015). The usefulness of ozone treatment in spinal pain. Drug design, development and therapy, 9, 2677–2685. https://doi. org/10.2147/DDDT.S74518 Shallenberger, F. (2011). Prolozone™ – Regenerating Joints and Eliminating Pain. Journal of Prolotherapy Smith, N. L. et al. (2017). Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. 3. 4. www.Cndoctor.ca CND_Contemporary Medical_JulyAug21_CSA.indd 1 July/August 2021 Chiropractic and Naturopathic Doctor 11 2021-07-05 11:55 AM
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