From N-Terminal Fragment of the Prohormone Brain-Type Natriuretic Peptide (NT-proBNP), Cardiovascular Events, and Mortality in Patients with Stable Coronary Heart Disease “Elevated levels of NT-proBNP predict cardiovascular morbidity and mortality, in- dependent of other prognostic markers, and identify at-risk individuals even in the absence of systolic or diastolic dysfunction by echocardiography. Level of NT-proBNP may help guide risk stratification of high-risk individuals, such as those with coronary heart disease.” “Why elevations in NT-proBNP level predict adverse cardiovascular outcomes is a subject of substantial investigation. Elevations of NT-proBNP level may refl ect subclini- cal levels of ventricular dysfunction or inducible ischemia not detectable by standard echocardiographic or stress test measures. Because natriuretic peptides are secreted from the ventricle in response to wall stress from volume or pressure overload, eleva- tions in NT-proBNP level may also signal important adverse hemodynamic alterations not captured in these other measures.” 9 Dr. Page, a Harvard researcher, is committed to developing a proposal to conduct research into the clinical and scientific ramifications of the matrix repatterning technique. NEW HORIZONS Dr. John Page, MBBS, MSc, ScD, research scientist and an assistant professor in epidemiology in the School of Public Health at Harvard University. patterning releases tension in deep core structures, such as bone, 7,8 Based on the premise that matrix re- and the sup- porting fascial elements surrounding var- ious organs, including the heart, it was only natural that we became interested in evaluating the levels of BNP in relation to our therapeutic interventions. Under Dr. Page’s supervision, we have now de- veloped a research proposal to evaluate the effect of matrix repatterning on this marker. Preliminary results are promis- ing. 18 • CANADIAN CHIROPRACTOR | APRIL 2008 Further potential areas of investigation of the effi cacy of matrix repatterning in- clude the evaluation of osseous changes related to mechanical osteoarthritis, up- per airway obstruction related to snoring and apnea, pelvic dysfunction – which we have determined to be commonly associated with urinary incontinence, infertility and erectile dysfunction – and gastro-esophageal refl ux – related to vis- ceral and diaphragmatic tension affecting hiatal closure. These clinical presenta- tions are routinely managed successfully with the use of matrix repatterning and clinical research is now being planned to further investigate this. The purpose of the research is to vali- date our clinical fi ndings using standard randomized controlled studies. It is our hope that this will open the door for fur- ther professional and public interest in, and access to, matrix repatterning, which we feel can greatly benefi t a wide range of conditions associated with structural dysfunction. This would also provide practitioners, trained in these technolo- gies, the skills and scope to help alleviate suffering and limited function for a much wider proportion of patients. • References: 1. Roth GB. The Matrix Repatterning Program for Pain Relief: Self-treatment for Musculoskeletal Pain. Oakland, CA: New Harbinger, 2005. 2. Ingber DE. The architecture of life. Sci Am 1998;278:48-57. 3. Roth GB. A New Approach to Frozen Shoulder: A Pilot Study using Matrix Repat- terning. Presented, by invitation, at the 2nd Annual Conference of Canadian Chiroprac- tic Research Centers. 4. Roth GB. Snoring and Sleep Apnea, Structural Implications. American Chiro- practor, Vol. 27, Issue 4, 2005. 5. Roth GB. The Use of Matrix Repat- terning on a Case of Ankylosing Spondylitis: A Case Report. Presented, by invitation, to the University of Illinois School of Medi- cine. 6. Oschman JL. Energy Medicine – The Scientifi c Basis. Churchill Livingstone, New York, 2001. 7. Duncan RL. Transduction of mechani- cal strain in bone. ASGSB Bulletin 8:49-62, 1995. 8. Marino AA, Gross BD. Piezoelectricity in cementum, dentine and bone. Arch Oral Biol 1989;34:507-9. 9. Bibbins-Domingo K, Gupta R, et al. N-Terminal Fragment of the Prohormone Brain-Type Natriuretic Peptide (NT-proB- NP), Cardiovascular Events, and Mortality in Patients with Stable Coronary Heart Dis- ease. JAMA. 2007;297:169-176. www.canadianchiropractor.ca
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